CISPLATIN-ENCAPSULATED TRAIL-ENGINEERED EXOSOMES FROM HUMAN CHORION-DERIVED MSCS FOR TARGETED CERVICAL CANCER THERAPY

Cisplatin-encapsulated TRAIL-engineered exosomes from human chorion-derived MSCs for targeted cervical cancer therapy

Abstract Background Cisplatin (DDP) is an efficacious and widely applied chemotherapeutic drug for cervical cancer patients who are diagnosed as metastatic and inoperable, or desiring fertility preservation.Tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) selectively triggers cancer cells apoptosis by binding to cognate death r

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Cysteine depletion sensitizes prostate cancer cells to agents that enhance DNA damage and to immune checkpoint inhibition

Abstract Background Prostate Cancer (PCa) represents one of the most commonly diagnosed neoplasms in men and is associated with significant morbidity and mortality.Therapy resistance and significant side effects of current treatment strategies indicate Lid Switch the need for more effective agents to treat both androgen-dependent and androgen-indep

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Development and implementation of a sustainable COVID-19 training package for healthcare workers: Experience from a teaching hospital of North India

Background: With the impending threat of future COVID-19 waves, it is imperative that teaching hospitals develop, implement, and evaluate a systematic training program to render HCW elastic in delivering COVID-19 related services.We present our experience in developing, implementing, and evaluating a sustainable and scalable COVID-19 patient manage

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